Marburg virus evades interferon responses by a mechanism distinct from ebola virus.

Marburg virus evades interferon responses by a mechanism distinct from ebola virus.

Previous studies have demonstrated that Marburg viruses (MARV) and Ebola viruses (EBOV) inhibit interferon (IFN)-alpha/beta signaling but utilize different mechanisms. EBOV inhibits IFN signaling via its VP24 protein which blocks the nuclear accumulation of tyrosine phosphorylated STAT1. In contrast...

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Bibliographic Details
Main Authors: Charalampos Valmas, Melanie N Grosch, Michael Schümann, Judith Olejnik, Osvaldo Martinez, Sonja M Best, Verena Krähling, Christopher F Basler, Elke Mühlberger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2799553?pdf=render

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