Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation

Basal-like breast cancers (BLBCs) are aggressive, and their drivers are unclear. We have found that wild-type N-RAS is overexpressed in BLBCs but not in other breast cancer subtypes. Repressing N-RAS inhibits transformation and tumor growth, whereas overexpression enhances these processes even in pr...

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Bibliographic Details
Main Authors:	Ze-Yi Zheng, Lin Tian, Wen Bu, Cheng Fan, Xia Gao, Hai Wang, Yi-Hua Liao, Yi Li, Michael T. Lewis, Dean Edwards, Thomas P. Zwaka, Susan G. Hilsenbeck, Daniel Medina, Charles M. Perou, Chad J. Creighton, Xiang H.-F. Zhang, Eric C. Chang
Format:	Article
Language:	English
Published:	Elsevier 2015-07-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124715006567

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http://www.sciencedirect.com/science/article/pii/S2211124715006567

Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation

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