Prominin‐1‐expressing hepatic progenitor cells induce fibrogenesis in murine cholestatic liver injury

Prominin‐1‐expressing hepatic progenitor cells induce fibrogenesis in murine cholestatic liver injury

Abstract Cholestatic liver injury is associated with intrahepatic biliary fibrosis, which can progress to cirrhosis. Resident hepatic progenitor cells (HPCs) expressing Prominin‐1 (Prom1 or CD133) become activated and participate in the expansion of cholangiocytes known as the ductular reaction. Pre...

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Bibliographic Details
Main Authors: Michael Fenlon, Celia Short, Jiabo Xu, Nicolas Malkoff, Elaa Mahdi, Michelle Hough, Alison Glazier, Calvin Lee, Kinji Asahina, Kasper S. Wang
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Physiological Reports
Subjects:
Biliary atresia
cell lineage tracing
cholangiocyte
cholestasis
liver fibrosis
RNA‐seq
Online Access:https://doi.org/10.14814/phy2.14508

Internet

https://doi.org/10.14814/phy2.14508

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