Association between Predicted Effects of <i>TP53</i> Missense Variants on Protein Conformation and Their Phenotypic Presentation as Li-Fraumeni Syndrome or Hereditary Breast Cancer

Association between Predicted Effects of <i>TP53</i> Missense Variants on Protein Conformation and Their Phenotypic Presentation as Li-Fraumeni Syndrome or Hereditary Breast Cancer

Rare germline pathogenic <i>TP53</i> missense variants often predispose to a wide spectrum of tumors characterized by Li-Fraumeni syndrome (LFS) but a subset of variants is also seen in families with exclusively hereditary breast cancer (HBC) outcomes. We have developed a logistic regres...

Full description

Bibliographic Details
Main Authors: Yaxuan Liu, Olga Axell, Tom van Leeuwen, Robert Konrat, Pedram Kharaziha, Catharina Larsson, Anthony P. H. Wright, Svetlana Bajalica-Lagercrantz
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
Li-Fraumeni syndrome
hereditary breast cancer
germline <i>TP53</i> missense variants
quantitative prediction model
protein conformation
Online Access:https://www.mdpi.com/1422-0067/22/12/6345

Internet

https://www.mdpi.com/1422-0067/22/12/6345

Similar Items