Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study

Abstract Major depressive disorder (MDD) in the elderly is a risk factor for dementia, but the precise biological basis remains unknown, hampering the search for novel biomarkers and treatments. In this study, we performed metabolomics analysis of cerebrospinal fluid (CSF) from cognitively intact el...

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Bibliographic Details
Main Authors: Kenji Hashimoto, Tamaki Ishima, Yasunori Sato, Davide Bruno, Jay Nierenberg, Charles R. Marmar, Henrik Zetterberg, Kaj Blennow, Nunzio Pomara
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03836-0