Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells

Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells

Urinary acrolein adduct levels have been reported to be increased in both habitual smokers and type-2 diabetic patients. The impairment of glucose transport in skeletal muscles is a major factor responsible for glucose uptake reduction in type-2 diabetic patients. The effect of acrolein on glucose m...

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Bibliographic Details
Main Authors: Ching-Chia Wang, Huang-Jen Chen, Ding-Cheng Chan, Chen-Yuan Chiu, Shing-Hwa Liu, Kuo-Cheng Lan
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
acrolein
skeletal muscle
glucose metabolism
Akt
glucose transporter
Online Access:https://www.mdpi.com/1422-0067/22/13/7228

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https://www.mdpi.com/1422-0067/22/13/7228

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