Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers.

Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers.

Previous studies of the Sleeping Beauty (SB) transposon system, as an insertional mutagen in the germline of mice, have used reverse genetic approaches. These studies have led to its proposed use for regional saturation mutagenesis by taking a forward-genetic approach. Thus, we used the SB system to...

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Bibliographic Details
Main Authors: Aron M Geurts, Lara S Collier, Jennifer L Geurts, Leann L Oseth, Matthew L Bell, David Mu, Robert Lucito, Susan A Godbout, Laura E Green, Scott W Lowe, Betsy A Hirsch, Leslie A Leinwand, David A Largaespada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1584263?pdf=render

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http://europepmc.org/articles/PMC1584263?pdf=render

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