Bioengineered Bruch's-like extracellular matrix promotes retinal pigment epithelial differentiation

In the eye, the retinal pigment epithelium (RPE) adheres to a complex protein matrix known as Bruch's membrane (BrM). The aim of this study was to provide enriched conditions for RPE cell culture through the production of a BrM-like matrix. Our hypothesis was that a human RPE cell line would de...

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Bibliographic Details
Main Authors: Samuel McLenachan, Erwei Hao, Dan Zhang, Ling Zhang, Michael Edel, Fred Chen
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580816302072