Synthesis of dihydroquinazolines from 2-aminobenzylamine: N3-aryl derivatives with electron-withdrawing groups

Synthesis of dihydroquinazolines from 2-aminobenzylamine: N3-aryl derivatives with electron-withdrawing groups

The sequential N-functionalization of 2-aminobenzylamine (2-ABA) followed by cyclodehydration allowed for a straightforward and efficient synthesis of 3,4-dihydroquinazolines with N-aryl substituents bearing electron-withdrawing groups. The sequence involves an initial SNAr displacement, N-acylation...

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Bibliographic Details
Main Authors: Nadia Gruber, Jimena E. Díaz, Liliana R. Orelli
Format: Article
Language:English
Published: Beilstein-Institut 2018-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
cyclodehydrations
dihydroquinazolines
microwaves
nitrilium ions
PPSE
SNAr
Online Access:https://doi.org/10.3762/bjoc.14.227

Internet

https://doi.org/10.3762/bjoc.14.227

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