Selective selC-independent selenocysteine incorporation into formate dehydrogenases.

The formate dehydrogenases (Fdh) Fdh-O, Fdh-N, and Fdh-H, are the only proteins in Escherichia coli that incorporate selenocysteine at a specific position by decoding a UGA codon. However, an excess of selenium can lead to toxicity through misincorporation of selenocysteine into proteins. To determi...

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Bibliographic Details
Main Authors: Michael Zorn, Christian H Ihling, Ralph Golbik, R Gary Sawers, Andrea Sinz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3636253?pdf=render