Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans

Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans

Abstract Background Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plastic networks amenable to intervention, th...

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Bibliographic Details
Main Authors: J. Alexander-Floyd, S. Haroon, M. Ying, A. A. Entezari, C. Jaeger, M. Vermulst, T. Gidalevitz
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Biology
Subjects:
Natural genetic variation
Regulatory variation
Cryptic variation
Protein aggregation
Proteostasis
Polyglutamine
Online Access:http://link.springer.com/article/10.1186/s12915-020-0750-5

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http://link.springer.com/article/10.1186/s12915-020-0750-5

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