Inhibition of Vascular Smooth Muscle Growth via Signaling Crosstalk between AMP-Activated Protein Kinase and cAMP-Dependent Protein Kinase

Inhibition of Vascular Smooth Muscle Growth via Signaling Crosstalk between AMP-Activated Protein Kinase and cAMP-Dependent Protein Kinase

Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings from our lab and others support growth control of VSM by adenosine monophosphate (AMP)-based approaches including the met...

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Bibliographic Details
Main Authors: Joshua Daniel Stone, Avinash eNarine, David Anthony Tulis
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Physiology
Subjects:
Migration
proliferation
AMPK
Protein Phosphatase
protein kinase A
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00409/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00409/full

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