Genetic Mutations and Mitochondrial Toxins Shed New Light on the Pathogenesis of Parkinson's Disease

The cellular abnormalities in Parkinson's disease (PD) include mitochondrial dysfunction and oxidative damage, which are probably induced by both genetic predisposition and environmental factors. Mitochondrial dysfunction has long been implicated in the pathogenesis of PD. The recent discovery...

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Bibliographic Details
Main Authors: Shigeto Sato, Nobutaka Hattori
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.4061/2011/979231