Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm

Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm

Tissue hypoxia controls cell differentiation in the embryonic pancreas, and promotes tumor growth in pancreatic cancer. The cellular response to hypoxia is controlled by the hypoxia-inducible factor (HIF) proteins, including HIF2α. Previous studies of HIF action in the pancreas have relied on loss-o...

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Bibliographic Details
Main Authors: Heather K. Schofield, Manuj Tandon, Min-Jung Park, Christopher J. Halbrook, Sadeesh K. Ramakrishnan, Esther C. Kim, Jiaqi Shi, M. Bishr Omary, Yatrik M. Shah, Farzad Esni, Marina Pasca di Magliano
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Pancreas
Hypoxia
HIF2α
KrasG12D
Chronic Pancreatitis
Mucinous Cystic Neoplasm
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X17301558

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http://www.sciencedirect.com/science/article/pii/S2352345X17301558

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