Enhanced Antitumor Response to Immune Checkpoint Blockade Exerted by Cisplatin-Induced Mutagenesis in a Murine Melanoma Model

Enhanced Antitumor Response to Immune Checkpoint Blockade Exerted by Cisplatin-Induced Mutagenesis in a Murine Melanoma Model

Sequencing data from different types of cancers including melanomas demonstrate that tumors with high mutational loads are more likely to respond to immune checkpoint blockade (ICB) therapies. We have previously shown that low-dose intratumoral injection of the chemotherapeutic DNA damaging drug cis...

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Bibliographic Details
Main Authors: Falih M. Gorgun, Steven G. Widen, Douglas S. Tyler, Ella W. Englander
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
cisplatin
CD8 T lymphocyte
immune checkpoint blockade
lymph node
melanoma
mutagenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.701968/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.701968/full

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