Comprehensive Analysis of Copy Number Variations in Kidney Cancer by Single-Cell Exome Sequencing

Comprehensive Analysis of Copy Number Variations in Kidney Cancer by Single-Cell Exome Sequencing

Clear-cell renal cell carcinoma (ccRCC) is the most common and lethal subtype of kidney cancer. VHL and PBRM1 are the top two significantly mutated genes in ccRCC specimens, while the genetic mechanism of the VHL/PBRM1-negative ccRCC remains to be elucidated. Here we carried out a comprehensive anal...

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Bibliographic Details
Main Authors: Wenyang Zhou, Fan Yang, Zhaochun Xu, Meng Luo, Pingping Wang, Yu Guo, Huan Nie, Lifen Yao, Qinghua Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Genetics
Subjects:
copy number variations
single-cell exome sequencing
clear-cell renal cell carcinoma
receptor protein tyrosine kinase
signaling transduction pathway
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01379/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.01379/full

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