RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells

RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells

Abstract Background Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly characterized by retinal pigment epithelium (RPE) degeneration with accumulation of abnormal intracellular deposits (lipofuscin) and photoreceptor death. RPE is vital for the retina and integ...

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Bibliographic Details
Main Authors: George Inana, Christopher Murat, Weijun An, Xiang Yao, Ian R. Harris, Jing Cao
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Translational Medicine
Subjects:
Age-related macular degeneration
Cell therapy
Human umbilical tissue derived cells
Retinal pigment epithelium
Phagocytosis
Receptor tyrosine kinase
Online Access:http://link.springer.com/article/10.1186/s12967-018-1434-6

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http://link.springer.com/article/10.1186/s12967-018-1434-6

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