Telomere shortening sensitizes cancer cells to selected cytotoxic agents: in vitro and in vivo studies and putative mechanisms.

Telomere shortening sensitizes cancer cells to selected cytotoxic agents: in vitro and in vivo studies and putative mechanisms.

BACKGROUND: Telomere/telomerase system has been recently recognized as an attractive target for anticancer therapy. Telomerase inhibition results in tumor regression and increased sensitivity to various cytotoxic drugs. However, it has not been fully established yet whether the mediator of these eff...

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Main Authors: Orit Uziel, Einat Beery, Vladimir Dronichev, Katty Samocha, Sergei Gryaznov, Lola Weiss, Shimon Slavin, Michal Kushnir, Yardena Nordenberg, Claudette Rabinowitz, Baruch Rinkevich, Tania Zehavi, Meir Lahav
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2817744?pdf=render

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http://europepmc.org/articles/PMC2817744?pdf=render

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