Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency.

Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency.

Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H+-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that leads to embryonic senescence and accelerated aging symptom...

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Bibliographic Details
Main Authors: Tomoyuki Sasaki, Shanshan Lian, Jie Qi, Peter E Bayliss, Christopher E Carr, Jennifer L Johnson, Sujay Guha, Patrick Kobler, Sergio D Catz, Matthew Gill, Kailiang Jia, Daniel J Klionsky, Shuji Kishi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4072523?pdf=render

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http://europepmc.org/articles/PMC4072523?pdf=render

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