Bufalin Induces Apoptosis of Human Osteosarcoma U-2 OS Cells through Endoplasmic Reticulum Stress, Caspase- and Mitochondria-Dependent Signaling Pathways

Bufalin Induces Apoptosis of Human Osteosarcoma U-2 OS Cells through Endoplasmic Reticulum Stress, Caspase- and Mitochondria-Dependent Signaling Pathways

Bone cancer is one of the cancer-related diseases, and there are increased numbers of patients with bone cancer worldwide. Therefore the efficacy of treatment of bone cancer is considered extremely vital. Bufalin has been showed to have biological activities including anticancer activities in vitro...

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Bibliographic Details
Main Authors: Ching-Hsiao Lee, Yung-Luen Shih, Mei-Hui Lee, Man-Kuan Au, Yung-Liang Chen, Hsu-Feng Lu, Jing-Gung Chung
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Molecules
Subjects:
bufalin
human osteosarcoma U-2 OS cells
endoplasmic reticulum stress-dependent signaling pathways
caspase-dependent signaling pathways
mitochondria-dependent signaling pathways
Online Access:http://www.mdpi.com/1420-3049/22/3/437

Internet

http://www.mdpi.com/1420-3049/22/3/437

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