The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome

The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome

Abstract Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria pat...

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Bibliographic Details
Main Authors: Kinanga Kiaco, António Sebastião Rodrigues, Virgílio do Rosário, José Pedro Gil, Dinora Lopes
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Malaria Journal
Subjects:
Human polymorphism
CYP450
MDR1
Artemether–lumefantrine
Angola
Online Access:http://link.springer.com/article/10.1186/s12936-017-2006-6
id doaj-54118b330905434ca135e6f780f51845
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spelling doaj-54118b330905434ca135e6f780f518452020-11-25T00:23:57ZengBMCMalaria Journal1475-28752017-09-011611610.1186/s12936-017-2006-6The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcomeKinanga Kiaco0António Sebastião Rodrigues1Virgílio do Rosário2José Pedro Gil3Dinora Lopes4Unidade de Parasitologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de LisboaCentre for Toxicogenomics and Human Health, Genetics, Oncology and Human Toxicology, Universidade Nova de LisboaUnidade de Parasitologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de LisboaDrug Resistance Unit, Division of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska InstitutetGlobal Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, Universidade Nova de LisboaAbstract Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.http://link.springer.com/article/10.1186/s12936-017-2006-6Human polymorphismCYP450MDR1Artemether–lumefantrineAngola
collection DOAJ
language English
format Article
sources DOAJ
author Kinanga Kiaco
António Sebastião Rodrigues
Virgílio do Rosário
José Pedro Gil
Dinora Lopes
spellingShingle Kinanga Kiaco
António Sebastião Rodrigues
Virgílio do Rosário
José Pedro Gil
Dinora Lopes
The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
Malaria Journal
Human polymorphism
CYP450
MDR1
Artemether–lumefantrine
Angola
author_facet Kinanga Kiaco
António Sebastião Rodrigues
Virgílio do Rosário
José Pedro Gil
Dinora Lopes
author_sort Kinanga Kiaco
title The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title_short The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title_full The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title_fullStr The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title_full_unstemmed The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
title_sort drug transporter abcb1 c.3435c>t snp influences artemether–lumefantrine treatment outcome
publisher BMC
series Malaria Journal
issn 1475-2875
publishDate 2017-09-01
description Abstract Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.
topic Human polymorphism
CYP450
MDR1
Artemether–lumefantrine
Angola
url http://link.springer.com/article/10.1186/s12936-017-2006-6
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