Hypoxia Induced Heparan Sulfate Primes the Extracellular Matrix for Endothelial Cell Recruitment by Facilitating VEGF-Fibronectin Interactions

Hypoxia Induced Heparan Sulfate Primes the Extracellular Matrix for Endothelial Cell Recruitment by Facilitating VEGF-Fibronectin Interactions

Vascular endothelial growth factor-A (VEGF) is critical for the development, growth, and survival of blood vessels. Retinal pigmented epithelial (RPE) cells are a major source of VEGF in the retina, with evidence that the extracellular matrix (ECM)-binding forms are particularly important. VEGF asso...

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Bibliographic Details
Main Authors: Jo Ann Buczek-Thomas, Celeste B. Rich, Matthew A. Nugent
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
age-related macular degeneration
angiogenesis
endothelial cell
fibronectin
hypoxia
retina
vascular endothelial growth factor
Online Access:https://www.mdpi.com/1422-0067/20/20/5065

Internet

https://www.mdpi.com/1422-0067/20/20/5065

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