A Prime-Boost Immunization Strategy with Vaccinia Virus Expressing Novel gp120 Envelope Glycoprotein from a CRF02_AG Isolate Elicits Cross-Clade Tier 2 HIV-1 Neutralizing Antibodies

A Prime-Boost Immunization Strategy with Vaccinia Virus Expressing Novel gp120 Envelope Glycoprotein from a CRF02_AG Isolate Elicits Cross-Clade Tier 2 HIV-1 Neutralizing Antibodies

Development of new immunogens eliciting broadly neutralizing antibodies (bNAbs) is a main priority for the HIV-1 vaccine field. Envelope glycoproteins from non-B-non-C HIV-1clades have not been fully explored as components of a vaccine. We produced Vaccinia viruses expressing a truncated version of...

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Bibliographic Details
Main Authors: Rita Calado, Joana Duarte, Pedro Borrego, José Maria Marcelino, Inês Bártolo, Francisco Martin, Inês Figueiredo, Silvia Almeida, Luís Graça, Jorge Vítor, Frederico Aires da Silva, Inês Dias, Belmira Carrapiço, Nuno Taveira
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Vaccines
Subjects:
HIV-1 vaccine
Recombinant Vaccinia virus
envelope glycoproteins
non-B-non-C clades
BALB/c mice
New Zealand White rabbits
Online Access:https://www.mdpi.com/2076-393X/8/2/171

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https://www.mdpi.com/2076-393X/8/2/171

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