Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia

Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia

Most patients with chronic lymphocytic leukemia (CLL) exhibit an indolent disease course and unresponsive B cell receptors (BCRs) exemplified by an anergic phenotype of their leukemic cells. In up to 5% of patients, CLL transforms from an indolent subtype to an aggressive form of B cell lymphoma (Ri...

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Bibliographic Details
Main Authors: Melanie Märklin, Alexander R. Fuchs, Claudia Tandler, Jonas S. Heitmann, Helmut R. Salih, Joseph Kauer, Leticia Quintanilla-Martinez, Stefan Wirths, Hans-Georg Kopp, Martin R. Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
CLL
NFAT2
NFATc1
LCK
Richter's transformation
anergy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01995/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01995/full

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