Striatal Network Models of Huntington's Disease Dysfunction Phenotypes

We present a network model of striatum, which generates “winnerless” dynamics typical for a network of sparse, unidirectionally connected inhibitory units. We observe that these dynamics, while interesting and a good match to normal striatal electrophysiological recordings, are fragile. Specifically...

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Bibliographic Details
Main Authors: Pengsheng Zheng, James Kozloski
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Computational Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fncom.2017.00070/full