The SCA1 (Spinocerebellar ataxia type 1) and MJD (Machado-Joseph disease) CAG repeats in normal individuals: segregation analysis and allele frequencies

The SCA1 (Spinocerebellar ataxia type 1) and MJD (Machado-Joseph disease) CAG repeats in normal individuals: segregation analysis and allele frequencies

Spinocerebellar ataxia type 1 (SCA1) and Machado-Joseph disease (MJD/SCA3) are autosomal dominant neurodegenerative diseases caused by expansions of a CAG trinucleotide repeat in the SCA1 and MJD genes. These expanded sequences are unstable upon transmission, leading to an intergeneration increase i...

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Bibliographic Details
Main Authors: Cláudia Emília Vieira Wiezel, Maria do Carmo Tomitão Canas, Aguinaldo Luiz Simões
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2003-01-01
Series:Genetics and Molecular Biology
Subjects:
segregation distortion
Spinocerebellar ataxia type 1
Machado-Joseph disease
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000200002

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000200002

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