Deletion of Mir223 Exacerbates Lupus Nephritis by Targeting S1pr1 in Faslpr/lpr Mice

Deletion of Mir223 Exacerbates Lupus Nephritis by Targeting S1pr1 in Faslpr/lpr Mice

ObjectiveThe micro RNAs (miRNAs) and their target mRNAs are differentially expressed in various immune-mediated cells. Here, we investigated the role of Mir223 and sphingosine-1-phosphate receptor 1 (S1pr1) in the pathogenesis of systemic lupus erythematosus.MethodsWe analyzed miRNA and mRNA profili...

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Bibliographic Details
Main Authors: Sumie Hiramatsu-Asano, Katsue Sunahori-Watanabe, Sonia Zeggar, Eri Katsuyama, Tomoyuki Mukai, Yoshitaka Morita, Jun Wada
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
miR-223-3p
S1pr1
S1PR1+CD4+ T cells
lupus nephritis
MRL/MpJ-Faslpr/J mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.616141/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.616141/full

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