Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis.

Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis.

New therapeutic strategies are needed to treat drug resistant tuberculosis (TB) and to improve treatment for drug sensitive TB. Pyrazinamide (PZA) is a critical component of current first-line TB therapy. However, the rise in PZA-resistant TB cases jeopardizes the future utility of PZA. To address t...

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Bibliographic Details
Main Authors: Stephanie A Montgomery, Ellen F Young, Phillip G Durham, Katelyn E Zulauf, Laura Rank, Brittany K Miller, Jennifer D Hayden, Feng-Chang Lin, John T Welch, Anthony J Hickey, Miriam Braunstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6160074?pdf=render

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http://europepmc.org/articles/PMC6160074?pdf=render

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