Xanthohumol Inhibited Mechanical Stimulation-Induced Articular ECM Degradation by Mediating lncRNA GAS5/miR-27a Axis

Xanthohumol Inhibited Mechanical Stimulation-Induced Articular ECM Degradation by Mediating lncRNA GAS5/miR-27a Axis

Osteoarthritis (OA) is histopathologically marked by extracellular matrix (ECM) degradation in joint cartilage. Abnormal mechanical stimulation on joint cartilage may result in ECM degeneration and OA development. Matrix metalloproteinase 13 (MMP-13) is one of the catabolic enzymes contributing to t...

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Bibliographic Details
Main Authors: Tiansheng Zheng, Qingluo Zhou, Jishang Huang, Jinliang Lai, Guanglin Ji, Dechao Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
osteoarthritis
extracellular matrix
mmp-13
xanthohumol
Gas5
miR-27a
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.737552/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.737552/full

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