The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-ε4 non-carriers in the Italian Alzheimer’s disease population and does not affect the plasma Aβ(1–42) level

The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-ε4 non-carriers in the Italian Alzheimer’s disease population and does not affect the plasma Aβ(1–42) level

Sporadic Alzheimer’s disease (AD) is the most frequent form of dementia in the elderly. A non-conservative polymorphism in the urokinase-type plasminogen activator gene (PLAU_1=RS2227564) has been analyzed, but data are conflicting on whether it is a risk factor for AD. To clarify whether this genet...

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Bibliographic Details
Main Authors: Marzia Pesaresi, Sara Batelli, Francesca Prato, Letizia Polito, Carlo Lovati, Elio Scarpini, Pierluigi Quadri, Claudio Mariani, Diego Albani, Gianluigi Forloni
Format: Article
Language:English
Published: Elsevier 2007-03-01
Series:Neurobiology of Disease
Subjects:
Urokinase-type plasminogen activator
PLAU_1
rs2227564
Amyloid-β protein (1–42)
Alzheimer’s disease
Genetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002956

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http://www.sciencedirect.com/science/article/pii/S0969996106002956

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