Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides.

Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides.

Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cells. Uninfected DCs capture HIV-1 and mediate viral transfer to bystander CD4(+) T cells through a process termed...

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Bibliographic Details
Main Authors: Nuria Izquierdo-Useros, Maier Lorizate, Maria C Puertas, Maria T Rodriguez-Plata, Nadine Zangger, Elina Erikson, Maria Pino, Itziar Erkizia, Bärbel Glass, Bonaventura Clotet, Oliver T Keppler, Amalio Telenti, Hans-Georg Kräusslich, Javier Martinez-Picado
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3525531?pdf=render

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http://europepmc.org/articles/PMC3525531?pdf=render

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