Antitumour Activity of the Ribonuclease Binase from <i>Bacillus pumilus</i> in the RLS<sub>40</sub> Tumour Model Is Associated with the Reorganisation of the miRNA Network and Reversion of Cancer-Related Cascades to Normal Functioning

Antitumour Activity of the Ribonuclease Binase from <i>Bacillus pumilus</i> in the RLS<sub>40</sub> Tumour Model Is Associated with the Reorganisation of the miRNA Network and Reversion of Cancer-Related Cascades to Normal Functioning

The important role of miRNA in cell proliferation and differentiation has raised interest in exogenous ribonucleases (RNases) as tools to control tumour-associated intracellular and extracellular miRNAs. In this work, we evaluated the effects of the RNase binase from <i>Bacillus pumilus</i&...

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Bibliographic Details
Main Authors: Islam Saber Ead Mohamed, Aleksandra V. Sen’kova, Alsu I. Nadyrova, Innokenty A. Savin, Andrey V. Markov, Vladimir A. Mitkevich, Aleksander A. Makarov, Olga N. Ilinskaya, Nadezhda L. Mironova, Marina A. Zenkova
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomolecules
Subjects:
RNases
binase
cytotoxicity
miRNAs
antitumour activity
tumour models
Online Access:https://www.mdpi.com/2218-273X/10/11/1509

Internet

https://www.mdpi.com/2218-273X/10/11/1509

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