T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease

T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is the second most prevalent movement disorder characterized by up to 80% loss of dopamine (DA) neurons and accumulation of Lewy body deposits composed of α-synuclein (α-syn). Accumulation of α-syn is associated with microglial activation, leading to a pr...

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Bibliographic Details
Main Authors: Meena S. Subbarayan, Charles Hudson, Lauren D. Moss, Kevin R. Nash, Paula C. Bickford
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
Parkinson’s disease
α-synuclein
T cells
Dopamine
Microglia
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01911-4

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http://link.springer.com/article/10.1186/s12974-020-01911-4

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