Oxidative stress induces monocyte‐to‐myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma

Oxidative stress induces monocyte‐to‐myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma

Abstract Background Cancer‐associated fibroblasts (CAFs) are among the most prominent cells during the desmoplastic reaction in pancreatic ductal adenocarcinoma (PDAC). However, CAFs are heterogeneous and the precise origins are not fully elucidated. This study aimed to explore whether monocytes can...

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Bibliographic Details
Main Authors: Xin Huang, Chaobin He, Xin Hua, Anna Kan, Yize Mao, Shuxin Sun, Fangting Duan, Jun Wang, Peng Huang, Shengping Li
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Clinical and Translational Medicine
Subjects:
monocyte‐to‐myofibroblast transdifferentiation
oxidative stress
p38
p53
pancreatic ductal adenocarcinoma
Online Access:https://doi.org/10.1002/ctm2.41

Internet

https://doi.org/10.1002/ctm2.41

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