Molecular Mechanisms of Pharmaceutical Drug Binding into Calsequestrin

Molecular Mechanisms of Pharmaceutical Drug Binding into Calsequestrin

Calsequestrin (CASQ) is a major Ca2+-storage/buffer protein present in the sarcoplasmic reticulum of both skeletal (CASQ1) and cardiac (CASQ2) muscles. CASQ has significant affinity for a number of pharmaceutical drugs with known muscular toxicities. Our approach, with in silico molecular docking, s...

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Bibliographic Details
Main Authors: ChulHee Kang, Emiliano J. Sanchez, Hendrik Milting, Ashwin K. Muralidharan, Arun K. Subra, Mark S. Nissen, Kevin M. Lewis
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:International Journal of Molecular Sciences
Subjects:
CASQ
calsequestrin
SR
sarcoplasmic reticulum
CASQ2
cardiac calsequestrin
CASQ1
skeletal calsequestrin
TFP
trifluoperazine
ITC
isothermal titration calorimetry
daunomycin
DAN
desipramine
DSP
diltiazem
DTZ
propafenone
PFN
thioridazine
TDZ
Online Access:http://www.mdpi.com/1422-0067/13/11/14326

Internet

http://www.mdpi.com/1422-0067/13/11/14326

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