Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

Atrial fibrillation (AF) and sinus bradycardia have been reported in patients with short QT syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 encoding the α subunit of channels carrying slow delayed rectifier potassium current, IKs. However, the mechanism(s) underl...

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Bibliographic Details
Main Authors: Dominic G. Whittaker, Michael A. Colman, Haibo Ni, Jules C. Hancox, Henggui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
anti-arrhythmic
arrhythmia
short QT syndrome
atrial fibrillation
KCNQ1 mutations
sinus bradycardia
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01402/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.01402/full

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