Rosmarinic acid inhibits proliferation and migration, promotes apoptosis and enhances cisplatin sensitivity of melanoma cells through inhibiting ADAM17/EGFR/AKT/GSK3β axis

Rosmarinic acid inhibits proliferation and migration, promotes apoptosis and enhances cisplatin sensitivity of melanoma cells through inhibiting ADAM17/EGFR/AKT/GSK3β axis

Rosmarinic acid (RA), a naturally occurring polyphenolic compound, exerts multiple biological properties including anti-cancer. The metalloprotease, a disintegrin and metalloproteinase 17 (ADAM17), can activate ligands of the epidermal growth factor receptor (EGFR) and contribute to tumor progressio...

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Bibliographic Details
Main Authors: Lin Huang, Jiangyan Chen, Jin Quan, Debing Xiang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Bioengineered
Subjects:
rosmarinic acid
melanoma
cisplatin
adam17
Online Access:http://dx.doi.org/10.1080/21655979.2021.1941699

Internet

http://dx.doi.org/10.1080/21655979.2021.1941699

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