Insights into Alzheimer disease pathogenesis from studies in transgenic animal models

Insights into Alzheimer disease pathogenesis from studies in transgenic animal models

Alzheimer disease is the most common cause of dementia among the elderly, accounting for ~60-70% of all cases of dementia. The neuropathological hallmarks of Alzheimer disease are senile plaques (mainly containing p-amyloid peptide derived from amyloid precursor protein) and neurofibrillary tangles...

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Bibliographic Details
Main Authors: Evelin L. Schaeffer, Micheli Figueiro, Wagner F. Gattaz
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2011-01-01
Series:Clinics
Subjects:
Neurodegenerative disorder
Senile plaques
Neurofibrillary tangles
Neuronal loss
Animal models
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011001300006

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011001300006

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