A 3D Heterotypic Breast Cancer Model Demonstrates a Role for Mesenchymal Stem Cells in Driving a Proliferative and Invasive Phenotype

A 3D Heterotypic Breast Cancer Model Demonstrates a Role for Mesenchymal Stem Cells in Driving a Proliferative and Invasive Phenotype

Previous indirect 2D co-culture studies have demonstrated that mesenchymal stem cells (MSCs) promote breast cancer (BC) progression through secretion of paracrine factors including growth factors, cytokines and chemokines. In order to investigate this aspect of the tumour microenvironment in a more...

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Bibliographic Details
Main Authors: Amarnath Pal, Jennifer C. Ashworth, Pamela Collier, Catherine Probert, Sal Jones, Eduardo Pernaut Leza, Marian L. Meakin, Alison A. Ritchie, David Onion, Philip A Clarke, Cinzia Allegrucci, Anna M. Grabowska
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
spheroid co-culture model
tumour stroma
mesenchymal stem cells (MSCs)
tumour microenvironment (TME)
epithelial-mesenchymal transition (EMT)
ski-related novel protein N (SnON)
Online Access:https://www.mdpi.com/2072-6694/12/8/2290

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https://www.mdpi.com/2072-6694/12/8/2290

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