Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors

Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors

All pathogens must acquire nutrients from their hosts. The intracellular bacterial pathogen Legionella pneumophila, the etiological agent of Legionnaires’ disease, requires host amino acids for growth within cells. The mechanistic target of rapamycin complex 1 (mTORC1) is an evolutionarily conserved...

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Bibliographic Details
Main Authors: Justin A. De Leon, Jiazhang Qiu, Christopher J. Nicolai, Jessica L. Counihan, Kevin C. Barry, Li Xu, Rosalie E. Lawrence, Brian M. Castellano, Roberto Zoncu, Daniel K. Nomura, Zhao-Qing Luo, Russell E. Vance
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
mTORC1
Legionella pneumophila
effector
amino acids
T4SS
amino-acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717315516

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http://www.sciencedirect.com/science/article/pii/S2211124717315516

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