Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers

Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers

Abstract The human mitochondrial ClpXP protease complex (HsClpXP) has recently attracted major attention as a target for novel anti-cancer therapies. Despite its important role in disease progression, the cellular role of HsClpXP is poorly characterized and only few small molecule inhibitors have be...

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Bibliographic Details
Main Authors: Martina Meßner, Melanie M. Mandl, Mathias W. Hackl, Till Reinhardt, Maximilian A. Ardelt, Karolina Szczepanowska, Julian E. Frädrich, Jens Waschke, Irmela Jeremias, Anja Fux, Matthias Stahl, Angelika M. Vollmar, Stephan A. Sieber, Johanna Pachmayr
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90801-7

Internet

https://doi.org/10.1038/s41598-021-90801-7

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