Simultaneous Determination of Chlorogenic Acid Isomers and Metabolites in Rat Plasma Using LC-MS/MS and Its Application to A Pharmacokinetic Study Following Oral Administration of Stauntonia Hexaphylla Leaf Extract (YRA-1909) to Rats

Simultaneous Determination of Chlorogenic Acid Isomers and Metabolites in Rat Plasma Using LC-MS/MS and Its Application to A Pharmacokinetic Study Following Oral Administration of Stauntonia Hexaphylla Leaf Extract (YRA-1909) to Rats

Stauntonia hexaphylla leaf extract (YRA-1909), which is widely used for the antirheumatic properties, has been under phase 2 clinical trials in patients with rheumatoid arthritis since April 2017. Liquid chromatography-tandem mass spectrometric method while using liquid–liquid extraction w...

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Bibliographic Details
Main Authors:	Won-Gu Choi, Ju-Hyun Kim, Dong Kyun Kim, Yongnam Lee, Ji Seok Yoo, Dae Hee Shin, Hye Suk Lee
Format:	Article
Language:	English
Published:	MDPI AG 2018-09-01
Series:	Pharmaceutics
Subjects:	Stauntonia hexaphylla leaf extract YRA-1909 pharmacokinetics chlorogenic acid neochlorogenic acid cryptochlorogenic acid caffeic acid caffeic acid O-glucuronides LC-MS/MS
Online Access:	http://www.mdpi.com/1999-4923/10/3/143

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