RAD51-Mediated DNA Homologous Recombination Is Independent of <i>PTEN</i> Mutational Status

RAD51-Mediated DNA Homologous Recombination Is Independent of <i>PTEN</i> Mutational Status

PTEN mutation occurs in a variety of aggressive cancers and is associated with poor patient outcomes. Recent studies have linked mutational loss of <i>PTEN</i> to reduced RAD51 expression and function, a key factor involved in the homologous recombination (HR) pathway. However, these stu...

Full description

Bibliographic Details
Main Authors: Asha Sinha, Ali Saleh, Raelene Endersby, Shek H. Yuan, Chirayu R. Chokshi, Kevin R. Brown, Bozena Kuzio, Tiina Kauppinen, Sheila K. Singh, Suzanne J. Baker, Peter J. McKinnon, Sachin Katyal
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
PTEN
RAD51
homologous recombination
DNA damage
γH2AX foci
RAD51 foci
Online Access:https://www.mdpi.com/2072-6694/12/11/3178

Internet

https://www.mdpi.com/2072-6694/12/11/3178

Similar Items