Protein nanofibril design via manipulation of hydrogen bonds

How the structure of fibril-forming peptides influences the material and structural characteristics of their resultant assemblies remains an open question. Here, aliphatic to aromatic amino acid substitution in such peptides is shown to have little effect on the tendency to form amyloid-like fibrils...

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Bibliographic Details
Main Authors: Nidhi Aggarwal, Dror Eliaz, Hagai Cohen, Irit Rosenhek-Goldian, Sidney R. Cohen, Anna Kozell, Thomas O. Mason, Ulyana Shimanovich
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-021-00494-2