Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity Against Coronaviruses

Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity Against Coronaviruses

The synthesis of α-fluorinated methyl ketones has always been challenging. New methods based on the homologation chemistry via nucleophilic halocarbenoid transfer, carried out recently in our labs, allowed us to design and synthesize a target-directed dipeptidyl α,α-difluoromethyl ketone (DFMK) <...

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Bibliographic Details
Main Authors: Andrea Citarella, Davide Gentile, Antonio Rescifina, Anna Piperno, Barbara Mognetti, Giorgio Gribaudo, Maria Teresa Sciortino, Wolfgang Holzer, Vittorio Pace, Nicola Micale
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
coronavirus
cysteine proteases
hCoV-229E
SARS-CoV-2 Mpro
difluoromethyl ketone
Online Access:https://www.mdpi.com/1422-0067/22/3/1398

Internet

https://www.mdpi.com/1422-0067/22/3/1398

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