4-Octyl Itaconate Activates Nrf2 Signaling to Inhibit Pro-Inflammatory Cytokine Production in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients

4-Octyl Itaconate Activates Nrf2 Signaling to Inhibit Pro-Inflammatory Cytokine Production in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients

Background/Aims: Increased production of multiple pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, plays an essential pathogenic role in the progression of systemic lupus erythematosus (SLE). Recent studies have characterized itaconate as a novel an...

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Bibliographic Details
Main Authors: Chun Tang, Xiaohua Wang, Yingying Xie, Xiaoyan Cai, Na Yu, Yudan Hu, Zhihua Zheng
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
SLE
PBMCs
4-octyl itaconate
Nrf2 signaling
Pro-inflammatory cytokines
Online Access:https://www.karger.com/Article/FullText/495400

Internet

https://www.karger.com/Article/FullText/495400

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