Severe COVID-19 Patients Show an Increase in Soluble TNFR1 and ADAM17, with a Relationship to Mortality

Severe COVID-19 Patients Show an Increase in Soluble TNFR1 and ADAM17, with a Relationship to Mortality

Overproduction of inflammatory cytokines is a keystone event in COVID-19 pathogenesis; TNF and its receptors (TNFR1 and TNFR2) are critical pro-inflammatory molecules. ADAM17 releases the soluble (sol) forms of TNF, TNFR1, and TNFR2. This study evaluated TNF, TNFRs, and ADAM17 at the protein, transc...

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Bibliographic Details
Main Authors: Yadira Palacios, Andy Ruiz, Lucero A. Ramón-Luing, Ranferi Ocaña-Guzman, Omar Barreto-Rodriguez, Anahí Sánchez-Monciváis, Brenda Tecuatzi-Cadena, Ana G. Regalado-García, Rey David Pineda-Gudiño, Alicia García-Martínez, Fortunato Juárez-Hernández, Juan Pablo Farias-Contreras, Ingrid Fricke-Galindo, Gloria Pérez-Rubio, Ramcés Falfán-Valencia, Ivette Buendia-Roldan, Karen Medina-Quero, Leslie Chavez-Galan
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
COVID-19
solTNF
solTNFR1
solTNFR2
ADAM17
severity
Online Access:https://www.mdpi.com/1422-0067/22/16/8423

Internet

https://www.mdpi.com/1422-0067/22/16/8423

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