Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity
α-synuclein (aSyn) expression is implicated in neurodegenerative processes, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). In animal models of these diseases, axon pathology often precedes cell death, raising the question of whether aSyn has compartment-specific toxic effect...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2014-05-01
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Series: | Disease Models & Mechanisms |
Subjects: | |
Online Access: | http://dmm.biologists.org/content/7/5/571 |