Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity

Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity

α-synuclein (aSyn) expression is implicated in neurodegenerative processes, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). In animal models of these diseases, axon pathology often precedes cell death, raising the question of whether aSyn has compartment-specific toxic effect...

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Bibliographic Details
Main Authors: Kelley C. O’Donnell, Aaron Lulla, Mark C. Stahl, Nickolas D. Wheat, Jeff M. Bronstein, Alvaro Sagasti
Format: Article
Language:English
Published: The Company of Biologists 2014-05-01
Series:Disease Models & Mechanisms
Subjects:
PGC1α
Alpha synuclein
Axon
Mitochondria
Neurodegeneration
Zebrafish
Online Access:http://dmm.biologists.org/content/7/5/571

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