Adult muscle-derived stem cells engraft and differentiate into insulin-expressing cells in pancreatic islets of diabetic mice

Adult muscle-derived stem cells engraft and differentiate into insulin-expressing cells in pancreatic islets of diabetic mice

Abstract Background Pancreatic beta cells are unique effectors in the control of glucose homeostasis and their deficiency results in impaired insulin production leading to severe diabetic diseases. Here, we investigated the potential of a population of nonadherent muscle-derived stem cells (MDSC) fr...

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Bibliographic Details
Main Authors: Violeta Mitutsova, Wendy Wai Yeng Yeo, Romain Davaze, Celine Franckhauser, El-Habib Hani, Syahril Abdullah, Patrice Mollard, Marie Schaeffer, Anne Fernandez, Ned J. C. Lamb
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Stem Cell Research & Therapy
Subjects:
Muscle stem cells
Beta-cell differentiation
Insulin secretion
Pancreatic islets
Online Access:http://link.springer.com/article/10.1186/s13287-017-0539-9

Internet

http://link.springer.com/article/10.1186/s13287-017-0539-9

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